TRANSiPORT new

MRP1    

MRP2

MRP3

MRP4

MRP8

BSEP

BCRP

Control

The products are licensed with the patent.

Vesicular Transport Assay Reagent Kit

ABC  Transporter  Products

Products  Lineup

 

ABC  Transporter  Products

GenoMembrane has excellent expertise and experience in the production of various drug transporters. We provide"ABC Transporter Vesicles", which are prepared from insect Sf9 cells expressing various ABC transporters.

ATPase assay and vesicular transport assay using our products are helpful to clarify the interactions between a compound of interest and ABC transporters.

・One vial of the vesicle producuts can perform 125 ATPase assays and 50 vesicular transport assays.

・The product size of all the products below is same. (2.5 mg/0.5 ml/vial)

・The products are suitable for in vitro screening of transporter substrates in a 96-well plate format.

・These products are expected to be useful tools for absorption, distribution, metabolism and excretion (ADME) and toxicological studies during drug development, as well as for studies on drug resistance mechanisms of anti-cancer drugs.

Products

A recent trend in drug development is to create new drugs that target a specific molecule identified by means of a genomic approach. Nevertheless, many drugs fail to reach clinical application, and costs associated with such unsuccessful drugs are high.

 

One of the major reasons for drop-out is inappropriate ADME (absorption, distribution, metabolism, and excretion) properties ofcandidates, resulting in low bioavailability or toxicity. It is, therefore, important to predict such problems at as early a stage as possible in the development process. GenoMembrane provides transporter reagents for this purpose.

GenoMembrane provides Transporter Membrane Vesicles and transporter expressing cell lines as research reagents.

MDR1    

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