TRANSiPORT new

 GM0015 Human MDR1

GM0004 Mouse Mdr1a

GM0016 Mouse Mdr1b

GM0010 Human MRP1

GM0011 Rat Mrp1

GM0017 Dog Mrp1

GM0001 Human MRP2

GM0002 Rat Mrp2

GM0014 Dog Mrp2

GM0022 Mouse Mrp2

GM0018 Monkey Mrp2

GM0021 Human MRP3

GM0012 Human MRP4

GM0020 Rat Mrp4

GM0013 Human MRP8

GM0008 Human BCRP

GM0007 Rat Bcrp

GM0005 Human BSEP

GM0006 Rat Bsep

GM0019 Dog Bsep

GM0003 Control

Reagent Kit for BSEP GM3001

Reagent Kit for MRPs GM3010

Reagent Kit for MDR1 GM3030 

MRP1    

MRP2

MRP3

MRP4

MRP8

BSEP

BCRP

Control

The products are licensed with the patent.

Vesicular Transport Assay Reagent Kit

ABC  Transporter  Products

Products  Lineup

 

ABC  Transporter  Products

GenoMembrane has excellent expertise and experience in the production of various drug transporters. We provide"ABC Transporter Vesicles", which are prepared from insect Sf9 cells expressing various ABC transporters.

ATPase assay and vesicular transport assay using our products are helpful to clarify the interactions between a compound of interest and ABC transporters.

・One vial of the vesicle producuts can perform 125 ATPase assays and 50 vesicular transport assays.

・The product size of all the products below is same. (2.5 mg/0.5 ml/vial)

・The products are suitable for in vitro screening of transporter substrates in a 96-well plate format.

・These products are expected to be useful tools for absorption, distribution, metabolism and excretion (ADME) and toxicological studies during drug development, as well as for studies on drug resistance mechanisms of anti-cancer drugs.

Products

A recent trend in drug development is to create new drugs that target a specific molecule identified by means of a genomic approach. Nevertheless, many drugs fail to reach clinical application, and costs associated with such unsuccessful drugs are high.

 

One of the major reasons for drop-out is inappropriate ADME (absorption, distribution, metabolism, and excretion) properties ofcandidates, resulting in low bioavailability or toxicity. It is, therefore, important to predict such problems at as early a stage as possible in the development process. GenoMembrane provides transporter reagents for this purpose.

GenoMembrane provides Transporter Membrane Vesicles and transporter expressing cell lines as research reagents.

MDR1