MATE1 is a new proton/organic cation exchanger, which is located mainly at the apical membrane of proximal cells of kidney and canalicular membrane of hepatocytes.
     MATE1 carries a wide variety of organic cations such as tetraethylammonium and metformin. MATE1 is predicted to exclude various drugs and metabolites from kidney and liver cells.

   GenoMembrane is proud to be the first organization licenced to offer research services on human, rat and mouse MATE1.

<References>

    Otsuka M, Matsumoto T, Morimoto T, Arioka S, Omote H, Moriyama Y. (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102(50): 17923-17928.

     Hiasa M, Matsumoto T, Komatsu T, Moriyama Y. (2006) Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. Am J Physiol Cell Physiol 291(4):C678-686.

     Omote H, Hiasa M, Matsumoto T, Otsuka M, Moriyama Y. (2006) The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci 27(11):587-593.